Catalog Number - 68018-P50-1503M

The 68018‑P50‑1503M Cogent RP C18 Wide Pore Process HPLC Column is engineered for high‑resolution biomolecule purification and industrial process chromatography, combining 10 µm particles with a 300 Å wide‑pore structure to deliver exceptional durability, extremely high loading capacity, and efficient analyte accessibility in continuous, large‑scale environments.

Manufactured using high‑purity 300 Å silica with traditional octadecylsilane (C18) bonding and fully double end‑capped, this stationary phase provides:

• Reduced silanol interactions

• Improved peak shape for proteins, peptides, and large polar analytes

• Consistent and reproducible performance in industrial‑scale and continuous purification workflows

The 300 Å pore structure enables large biomolecules to fully access the stationary phase, minimizing restricted diffusion and improving recovery compared to standard 100 Å media.

This column is ideal as a USP L1 alternate and as a high‑performance platform for final biomolecule purification in process‑scale manufacturing workflows.

150 mm Length – Maximum Resolution for Process Optimization

• Higher resolving power than 50 mm and 100 mm process columns

• Maximizes peak capacity for complex biomolecule mixtures

• Ideal for proteins, peptides, and closely related macromolecules

• Preferred for final purification and process refinement prior to full manufacturing runs

• Longer run times compared to shorter formats

This configuration is selected when maximum separation performance is required before final production or continuous processing deployment.

50 mm ID – Maximum Industrial‑Scale Loading

• Provides extremely high sample loading capacity (top tier across entire column ecosystem)

• Designed for industrial purification, batch production, and continuous processing workflows

• Supports ultra‑high‑flow chromatography systems

Typical Flow Rate Range

• ~50–150 mL/min (system dependent)

• Optimize based on process capability and production requirements

✅ Designed for process HPLC systems capable of ultra‑high flow rates and very large injection volumes

Flow Rate & System Considerations (50 mm ID, 10 µm, 300 Å)

• Requires systems capable of:

  • Ultra‑high flow rates

  • Very large injection volumes

• Compatible with:

  • Industrial chromatography systems

  • High‑capacity pumps and injection platforms

  • Large‑volume fraction collection or continuous processing systems

⚠️ Not suitable for analytical, semi‑prep, or standard preparative HPLC systems

Why Choose Wide Pore (300 Å) C18 (10 µm, Process Scale)

Designed for Biomolecules

• Enables purification of:

  • Proteins

  • Peptides

  • Large hydrophobic compounds

• Eliminates mass transfer limitations associated with smaller pore media

Maximum‑Resolution Industrial Platform

• Ideal for final‑stage purification at manufacturing scale

• Maximizes separation efficiency, recovery, and product purity

• Supports high‑purity biomolecule production workflows

Full Workflow Scalability

• Predictable performance across analytical → semi‑prep → prep → production → process

• Enables efficient method transfer and industrial scale‑up

Cogent RP C18™ Advantages

Fully End‑Capped Surface

• Minimizes secondary interactions

• Improves peak symmetry

• Enhances robustness in high‑load industrial environments

High Purity Silica

• Consistent chromatographic performance

• Reduced variability across large‑scale and continuous manufacturing runs

Durable & Cost‑Efficient

• Long column lifetime

• Designed for continuous, high‑throughput process workflows

• Reduces downtime and operational costs

Typical Applications

• Industrial‑scale biomolecule purification

• Protein and peptide separations

• High‑purity compound manufacturing

• Pharmaceutical production

• Process chromatography and scale‑up

• USP L1 wide‑pore reversed‑phase methods

Important Usage Notes

• Designed for 300 Å wide‑pore biomolecule applications

• Requires process‑scale HPLC system capability (50 mm ID)

• Ideal for maximum‑resolution purification prior to full production runs

• Optimize for resolution vs throughput based on manufacturing objectives

Made‑to‑Order & Pricing Information

This is a custom, made‑to‑order item.

• Orders cannot be canceled once placed

• Custom items are non‑returnable

• Please contact Customer Service for formal quotation, lead time, and ordering assistance. Classification:

• This item is classified as a CUSTOM ITEM. View our Custom Item policy.