Overview

Mobile phase reservoir bottles are designed for gravity-fed solvent delivery, not for pressure-driven operation. While the glass and safety coating are engineered for durability during normal handling, they are not built to withstand elevated internal pressures.

Understanding these limitations helps prevent dangerous bottle failures and ensures optimal chromatographic performance.

Pressure Guidelines for MICROSOLV Mobile Phase Bottles

1. Not Designed for Pressurization

MICROSOLV safety-coated and non-coated bottles are not pressure-rated and should not be used in any application that requires internal pressurization. Their intended use relies on gravity flow, with the bottles positioned above the HPLC system to allow solvent to feed naturally into the instrument.

2. Acceptable Low-Pressure Use (1–2 psi)

A very small amount of pressure—approximately 1–2 psi—is acceptable when gently pushing liquid in or out of the bottle. This limited pressure is generally safe and does not compromise the bottle structure or the safety coating.

This low-pressure threshold allows for operations such as controlled solvent transfer, but it should not be exceeded under any circumstances.

3. Pressures to Avoid

Do not expose these bottles to:

• Sustained internal pressure
• Pressures above 2 psi
• Any pressure-driven pumping system

Exceeding the safe limit risks:

• Cracking the glass
• Compromising the safety coating
• Sudden bottle failure

Why These Bottles Aren’t Pressure-Rated

The reservoir bottles are engineered with:

• Borosilicate glass designed for chemical compatibility
• Safety coatings (optional) intended for containment of fragments if broken

However, neither the coating nor the bottle structure has been stress‑tested or certified for internal pressure applications. Pressure use should be limited to gravity or minimal low-pressure assistance only.