Catalog Number - 68124-10P

Cogent RP Phenyl™ is a reversed-phase UHPLC stationary phase designed to provide enhanced selectivity for aromatic and structurally related compounds. Manufactured using a propyl linker with a terminal phenyl ring bonded to ultra-high purity silica and fully double end capped, this phase offers unique π-π interaction mechanisms that can improve the separation of compounds that may be difficult to resolve on traditional alkyl phases. It is particularly useful for aromatic pharmaceuticals, positional isomers, flavonoids, tocopherols, polynuclear aromatic hydrocarbons, nitro-aromatic compounds, and many natural products.

68124-10P is a UHPLC column packed with 1.8 µm RP Phenyl™ particles featuring a 100 Å pore size in a 4.6 mm ID x 100 mm format. The 100 mm length provides greater resolution and peak capacity than shorter 50 mm columns while maintaining efficient analysis times. The sub-2 µm particle technology delivers excellent chromatographic efficiency and is specifically designed for high-pressure UHPLC operation. Typical operating flow rates are approximately 1.0–2.0 mL/min depending on mobile phase composition, temperature, and system pressure limitations.

This column is ideal for aromatic compounds, positional isomers, APIs, flavonoids, natural products, and other phenyl-containing analytes when additional resolving power is needed. While compatible HPLC systems may be used if pressure limitations allow, this column is engineered primarily for UHPLC systems where the full benefits of sub-2 µm particle technology can be achieved.

Key Benefits

• RP Phenyl™ stationary phase

• Fully double end capped

• Propyl phenyl bonded phase

• Ultra-high purity silica support

• Enhanced aromatic selectivity

• π-π interaction capability

• Designed for UHPLC applications

• High-efficiency 1.8 µm particles

• Increased peak capacity

• Improved chromatographic resolution

Typical Applications

• Positional isomer separations

• Tocopherol analysis

• Flavonoid analysis

• Polynuclear aromatic hydrocarbon analysis

• Nitro-aromatic compound analysis

• API analysis

• Natural product analysis

• Pharmaceutical method development

• UHPLC analysis

• Complex aromatic compound separations

Specifications

• Product Type: UHPLC Column

• Stationary Phase: RP Phenyl™

• Chromatography Mode: Reversed Phase

• Bonded Phase: Propyl Phenyl

• Endcapping: Fully Double End Capped

• Particle Size: 1.8 µm

• Pore Size: 100 Å

• Column Dimensions: 4.6 mm ID x 100 mm

• Length: 100 mm

• Typical Flow Rate: 1.0–2.0 mL/min

• Brand: Cogent

Important Notes

• Specifically designed for UHPLC operation and high-pressure reversed-phase chromatography

• Delivers maximum performance when used on a UHPLC system designed for sub-2 µm particle columns

• May be used on compatible HPLC systems only if instrument pressure limits are not exceeded

• Sub-2 µm particles generate significantly higher backpressure than conventional HPLC columns

• The 100 mm length provides greater resolution and peak capacity than 50 mm columns

• Enhanced selectivity for aromatic and phenyl-containing compounds compared to traditional alkyl phases

• Samples should be filtered through a 0.2 µm syringe filter prior to injection

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