Ammonium fluoride offers several advantages when used as a mobile phase additive in LC-MS applications when used with Cogent TYPE-C HPLC Columns. The columns have a longer lifetime than standard HPLC columns due to the silica hydride particle that is somewhat resistant to the corrosove effects of the acid.
- Acts as a buffer, helping to control pH
- Enhances peak shapes, leading to better chromatographic performance
- Improves MS sensitivity for certain analytes
For more detailed information, refer to the following third-party journal article: J. Pesek, M. Matyska, "Ammonium fluoride as a mobile phase additive in aqueous normal phase chromatography," J. Chromatogr. A. 1401, 2015, pp. 69–74.
Important Note:
Ammonium fluoride is corrosive to glass, so Teflon containers are recommended. Additionally, concentrations above 1 mM may cause irreversible damage to HPLC columns. While Cogent TYPE-C™ Silica columns have been reported to exhibit greater durability compared to conventional columns, ammonium fluoride may still reduce their lifespan to some extent.
