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RSA Ordering Information

Best-in-Class Glass Vials & Inserts...

Sample containers for HPLC, CE or GC that will provide reliable, consistent results by not adsorbing basic analytes, add metal to your sample diluent or change the pH in your vial causing chromatography errors. Ordinary autosampler vials, even Certified Vials can result in data that is not precise and inaccurate causing investigations or decisions that are not valid.

RSA™ Vials are made with a unique, reduced surface activity glass (RSA™) developed specifically for labs investigating low-abundance analytes, samples that are pH sensitive, basic in nature or when using mass spectrometers.  Also used when surface coatings or silanization are not sufficient or counter indicated for good results RSA™ Vials are a great choice.

What is RSA™ Technology … the RSA™ proprietary manufacturing process does not create silanols (OH groups) on the Type 33, borosilicate glass, virtually eliminates surface metals and does not add the typical, residual microgram amounts of powders or grease found in other borosilicate glass vials. Our process takes into account that the converting from glass tubing to glass vial will create these artifacts in vials and we eliminated the root causes from start to packaging. Then vials are Quality Controlled for adsorption, metal content and residual materials that may cause a change in pH when using water as your diluent and a Certificate of QC Conformance is available upon request.

Every batch of RSA™ glass is tested… for basic compound adsorption, pH stability over time, metal counts as well as standard fit and form tolerance. Certificates of Conformance to these QC tests are available. Lot support for investigations are available as well at no charge if needed.

What does RSA™ glass do for you… when using all other borosilicate glass autosampler vials or glass inserts commercially available, sample diluents (such as water) can de-protonate the many hydroxyl groups on the wall of your vial which produces a negative charge on the glass. The “acidic” functionality of these silanols has been known to cause adsorption of basic compounds, and/or hydrolyze some susceptible compounds making them undetectable. The surface metals in your current vial contaminates and can cause precipitation, chelation or other changes in your samples while in the vial. Eliminating ordinary metals found in borosilicate glass vials will prevent adducts from forming when using LCMS. 
Benefits of Using RSA Glass Autosampler Vials and Inserts: 
Residual contaminants used as release agents for ordinary glass autosampler vial manufacturing processes can cause the pH of water based diluents to increase by up to 1.5 pH units in the vial over a four-hour period. RSA™ vials do not contain any of these common contaminants and gives you assurance that your chromatography will not change during this period due to invisible vial contamination.
Prevent hydrolysis in the vial. Hydroxyl groups found on the surface of all ordinary glass autosampler vials can be very acidic causing hydrolysis of bio active compounds. The RSA™ vial surface has virtually no silanols making them mostly inert for these types of compounds that are susceptible to acidic functionality.
Insure quantitation precision run to run, minimize sample desorption. The hydroxyl groups found on the surface of ordinary glass autosampler vials will bind basic compounds. RSA™ vials have no silanols and every batch is tested for low adsorption. Quantitation is very precise and eliminates an increase in RSD vial to vial and lot to lot. Prevent investigations due to glass vials retaining your samples which are especially noticeable in low sample concentrations or low dosage forms.
During the manufacturing process for all ordinary autosampler vials, if the process is not controlled properly, metals such as sodium accumulate on the surface of the glass. These elements create adducts that can cause issues for your LCMS data. All batches of RSA™ vials are tested for and have extremely low metal content, making them ideal for LCMS, LCMS/MS and GC/MS.
Prevent spurious peaks from glass. The RSA™ vial manufacturing process is conducted in an ultra-clean glass conversion facility without the use of any release agents, grease or glass additives. The entire process is fully automated and the vials are never touched by human hands. This provides assurance for the cleanest vials without a wash process which causes contamination of finished vials due to residue.
Protect your sample needle and instruments. RSA™ vials are manufactured with the same dimensional tolerances as the AQ™ Brand (Best-in the Industry) vials to meet the most demanding needs of all autosamplers on the market. This includes bottom height control which is critical for Waters© autosamplers. Compare RSA™ vials to the internal dimensional control of other HPLC and LCMS Certified™ products on the market.

NOTE: RSA™ autosampler vials and glass inserts are not manufactured with coatings; makes them an excellent choice for HPLC, LCMS, GC and GCMS applications when quantitation, reliability and accuracy are important. With standard borosilicate glass vials and inserts sample diluents (such as water) can de-protonate the many surface hydroxyl groups; producing a negative charge on the glass wall. The “acidic” functionality of silanols has been known to cause adsorption of basic compounds, change the sample solution pH and/or hydrolyze susceptible compounds rendering them undetectable. With RSA Glass™ vials and inserts there is virtually no sample “loss to the vial” and no “pH shifting” making your analysis more reliable.

You should use RSA Autosampler Vials... if you are working with low abundance basic samples with regular glass vials, it is very possible that some of your compounds could easily be adsorbed to the glass wall. This can change your quantitation or completely remove the compound from solution preventing injection and ultimately masking its detection and identification. With RSA Glass™ vials and inserts this will not occur if the adsorption is due to silanol interaction.

You should use RSA Autosampler Vials... if you are working with sensitive compounds commonly found in natural products, biological samples or chemical synthesis, the glass wall could be a problem for basic compounds. With RSA™ glass vials this problem is eliminated.

You should use RSA-Pro Surface Treated Autosampler Vials... if you are working with basic proteins that adsorb or are affected by silanols or normal glass siloxanes; RSA-Pro™ surface treated glass vials and inserts will be a good solution for you. If your proteins are sticking to the glass due to adsorption by the hydrophilic surface, RSA-Pro™ Glass provides an almost completely ion free, hydrophobic and an even less adsorptive surface. The low adsorption performance of RSA-Pro™ glass & permanent, covalent treatment over silanized glass is far superior for proteins and peptides especially when comparing adsorption consistency from vial to vial, even in the same package or when storing for extended periods of tim



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