Here are many compelling reasons to use Cogent TYPE-C™ HPLC columns for new method development. Below are some key advantages:

1. Simplified Method Design
   Traditional columns often require gradients to handle mixtures with large polarity differences. With TYPE-C™ columns, isocratic methods are often possible—even for complex mixtures—saving time and simplifying method development.

2. Retention of Challenging Compounds
   TYPE-C™ columns can retain compounds that previous column technologies cannot, offering solutions for difficult separations.

3. Rapid Mode Switching
   Unlike conventional silica columns, TYPE-C™ columns lack water shells. This means switching between Reversed Phase (RP), Aqueous Normal Phase (ANP), and Normal Phase (NP) is fast and virtually memory-free, enabling flexible workflows.

4. Multiple Separation Mechanisms
   These columns can combine RP and ANP mechanisms, and the choice of bonded phase allows fine-tuning for specific interactions—ideal for complex or untargeted analyses.

5. Superior Selectivity and Orthogonality
   TYPE-C™ columns provide exceptional selectivity and can even be orthogonal to themselves, making them unmatched for untargeted analysis and comprehensive profiling.

For a deeper dive into these benefits, see the attached White Paper "Why Labs Should Adopt TYPE-C Columns" link below.