HPLC Column, Diol 2.o, 2.2um, 2.1mm ID x 50mm Length, 120A. Cogent TYPE-C Brand. 1 EA.
TYPE‑C™ Diol Columns for RP, NP, ANP / HILIC, SFC, of Polar Compounds
Cogent Diol™ HPLC columns are highly versatile, TYPE‑C™ silica‑based diol columns designed to operate across three chromatographic modes: reversed phase (RP), normal phase (NP), and aqueous normal phase (ANP). This unique capability makes them an excellent choice for laboratories working with polar compounds, complex matrices, and modern LC‑MS workflows.
Thanks to proprietary bonding technology and silica hydride surface chemistry, Cogent Diol™ columns deliver exceptional stability, efficiency, and reproducibility across a wide range of mobile phases.
Proprietary TYPE‑C™ Silica Diol Chemistry
Unlike conventional diol columns, Cogent Diol™ HPLC columns are manufactured using TYPE‑C™ silica, which is based on a silica hydride surface rather than traditional silanol chemistry. This advanced surface dramatically improves column robustness while providing unique selectivity for challenging separations.
The diol functional group bonded to TYPE‑C™ silica enables:
Operation in RP, NP, and ANP modes
Broad solvent compatibility
Reduced silanol activity
Improved stability across gradient methods
Distinct retention behavior compared to conventional diol phases
Extremely Fast Equilibration for Gradient Methods
Cogent Diol™ columns are known for very fast equilibration between gradient runs, making them especially well suited for:
High‑throughput analytical workflows
Method development
LC‑MS applications
Complex gradient separations
This fast equilibration improves productivity and method reproducibility, particularly when working with polar analytes.
Ideal for HPLC, LC‑MS, and SFC
Cogent Diol™ HPLC columns are a powerful, multi‑purpose tool for modern separation laboratories. In addition to HPLC and LC‑MS, these columns are also suitable for supercritical fluid chromatography (SFC), offering added flexibility for laboratories using multiple separation techniques.
Typical Applications
Polar and highly polar compounds
RP, NP, and ANP HPLC separations
LC‑MS and LC‑MS/MS
Supercritical fluid chromatography (SFC)
Bioanalytical and pharmaceutical methods
Method development and optimization
Key Features and Benefits
TYPE‑C™ silica‑based diol phase
Operates in RP, NP, and ANP modes
Excellent for polar compounds
Extremely fast equilibration between gradients
High stability and efficiency
Broad solvent compatibility
Suitable for HPLC, LC‑MS, and SFC
Unique selectivity compared to conventional diol columns
Learn More and Technical Resources
Column Protection Recommendation
Important: MICROSOLV technical support strongly recommends using the Cogent Column Filter, which is included with each column, whenever possible. Column filters help protect the column from particulates, extend column lifetime, and maintain consistent chromatographic performance.
👉 Learn more about the Cogent Column Filter for HPLC column protection
